Near-infrared light treatment reduces astrogliosis in MPTP-treated monkeys.
Identifieur interne : 001A60 ( Main/Exploration ); précédent : 001A59; suivant : 001A61Near-infrared light treatment reduces astrogliosis in MPTP-treated monkeys.
Auteurs : Nabil El Massri [Australie] ; Cécile Moro [France] ; Napoleon Torres [France] ; Fannie Darlot [France] ; Diane Agay [France] ; Claude Chabrol [France] ; Daniel M. Johnstone [Australie] ; Jonathan Stone [Australie] ; Alim-Louis Benabid [France] ; John Mitrofanis [Australie]Source :
- Experimental brain research [ 1432-1106 ] ; 2016.
Descripteurs français
- KwdFr :
- 1-Méthyl-4-phényl-1,2,3,6-tétrahydropyridine (pharmacologie), Analyse de variance, Animaux, Corps strié (anatomopathologie), Corps strié (métabolisme), Femelle, Gliose (), Gliose (étiologie), Intoxication au MPTP (), Intoxication au MPTP (anatomopathologie), Macaca fascicularis, Modèles animaux de maladie humaine, Mâle, Neurotoxines (toxicité), Névroglie (), Névroglie (effets des radiations), Protéine gliofibrillaire acide (métabolisme), Protéines de liaison à l'ADN (métabolisme), Rayons infrarouges (usage thérapeutique), Substantia nigra (), Substantia nigra (anatomopathologie), Substantia nigra (métabolisme).
- MESH :
- anatomopathologie : Corps strié, Intoxication au MPTP, Substantia nigra.
- effets des radiations : Névroglie.
- métabolisme : Corps strié, Protéine gliofibrillaire acide, Protéines de liaison à l'ADN, Substantia nigra.
- pharmacologie : 1-Méthyl-4-phényl-1,2,3,6-tétrahydropyridine.
- toxicité : Neurotoxines.
- usage thérapeutique : Rayons infrarouges.
- étiologie : Gliose.
- Analyse de variance, Animaux, Femelle, Gliose, Intoxication au MPTP, Macaca fascicularis, Modèles animaux de maladie humaine, Mâle, Névroglie, Substantia nigra.
English descriptors
- KwdEn :
- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (pharmacology), Analysis of Variance, Animals, Corpus Striatum (metabolism), Corpus Striatum (pathology), DNA-Binding Proteins (metabolism), Disease Models, Animal, Female, Glial Fibrillary Acidic Protein (metabolism), Gliosis (etiology), Gliosis (therapy), Infrared Rays (therapeutic use), MPTP Poisoning (complications), MPTP Poisoning (pathology), Macaca fascicularis, Male, Neuroglia (drug effects), Neuroglia (radiation effects), Neurotoxins (toxicity), Substantia Nigra (drug effects), Substantia Nigra (metabolism), Substantia Nigra (pathology).
- MESH :
- chemical , metabolism : DNA-Binding Proteins, Glial Fibrillary Acidic Protein.
- chemical , pharmacology : 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
- complications : MPTP Poisoning.
- drug effects : Neuroglia, Substantia Nigra.
- etiology : Gliosis.
- metabolism : Corpus Striatum, Substantia Nigra.
- pathology : Corpus Striatum, MPTP Poisoning, Substantia Nigra.
- radiation effects : Neuroglia.
- therapeutic use : Infrared Rays.
- therapy : Gliosis.
- chemical , toxicity : Neurotoxins.
- Analysis of Variance, Animals, Disease Models, Animal, Female, Macaca fascicularis, Male.
Abstract
We have reported previously that intracranial application of near-infrared light (NIr) reduces clinical signs and offers neuroprotection in a subacute MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) monkey model of Parkinson's disease. In this study, we explored whether NIr reduces the gliosis in this animal model. Sections of midbrain (containing the substantia nigra pars compacta; SNc) and striatum were processed for glial fibrillary acidic protein (to label astrocytes; GFAP) and ionised calcium-binding adaptor molecule 1 (to label microglia; IBA1) immunohistochemistry. Cell counts were undertaken using stereology, and cell body sizes were measured using ImageJ. Our results showed that NIr treatment reduced dramatically (~75 %) MPTP-induced astrogliosis in both the SNc and striatum. Among microglia, however, NIr had a more limited impact in both nuclei; although there was a reduction in overall cell size, there were no changes in the number of microglia in the MPTP-treated monkeys after NIr treatment. In summary, we showed that NIr treatment influenced the glial response, particularly that of the astrocytes, in our monkey MPTP model of Parkinson's disease. Our findings raise the possibility of glial cells as a future therapeutic target using NIr.
DOI: 10.1007/s00221-016-4720-7
PubMed: 27377070
Affiliations:
- Australie, France
- Auvergne-Rhône-Alpes, Nouvelle-Galles du Sud, Rhône-Alpes
- Grenoble, Sydney
- Université de Sydney
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 001600
- to stream PubMed, to step Curation: 001578
- to stream PubMed, to step Checkpoint: 001578
- to stream Ncbi, to step Merge: 003799
- to stream Ncbi, to step Curation: 003799
- to stream Ncbi, to step Checkpoint: 003799
- to stream Main, to step Merge: 001A56
- to stream Main, to step Curation: 001A60
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Near-infrared light treatment reduces astrogliosis in MPTP-treated monkeys.</title>
<author><name sortKey="El Massri, Nabil" sort="El Massri, Nabil" uniqKey="El Massri N" first="Nabil" last="El Massri">Nabil El Massri</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Anatomy F13, University of Sydney, Sydney, 2006, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Anatomy F13, University of Sydney, Sydney, 2006</wicri:regionArea>
<orgName type="university">Université de Sydney</orgName>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Moro, Cecile" sort="Moro, Cecile" uniqKey="Moro C" first="Cécile" last="Moro">Cécile Moro</name>
<affiliation wicri:level="3"><nlm:affiliation>University Grenoble Alpes, CEA, LETI, CLINATEC, MINATEC Campus, 38000, Grenoble, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>University Grenoble Alpes, CEA, LETI, CLINATEC, MINATEC Campus, 38000, Grenoble</wicri:regionArea>
<placeName><settlement type="city">Grenoble</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Torres, Napoleon" sort="Torres, Napoleon" uniqKey="Torres N" first="Napoleon" last="Torres">Napoleon Torres</name>
<affiliation wicri:level="3"><nlm:affiliation>University Grenoble Alpes, CEA, LETI, CLINATEC, MINATEC Campus, 38000, Grenoble, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>University Grenoble Alpes, CEA, LETI, CLINATEC, MINATEC Campus, 38000, Grenoble</wicri:regionArea>
<placeName><settlement type="city">Grenoble</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Darlot, Fannie" sort="Darlot, Fannie" uniqKey="Darlot F" first="Fannie" last="Darlot">Fannie Darlot</name>
<affiliation wicri:level="3"><nlm:affiliation>University Grenoble Alpes, CEA, LETI, CLINATEC, MINATEC Campus, 38000, Grenoble, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>University Grenoble Alpes, CEA, LETI, CLINATEC, MINATEC Campus, 38000, Grenoble</wicri:regionArea>
<placeName><settlement type="city">Grenoble</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Agay, Diane" sort="Agay, Diane" uniqKey="Agay D" first="Diane" last="Agay">Diane Agay</name>
<affiliation wicri:level="3"><nlm:affiliation>University Grenoble Alpes, CEA, LETI, CLINATEC, MINATEC Campus, 38000, Grenoble, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>University Grenoble Alpes, CEA, LETI, CLINATEC, MINATEC Campus, 38000, Grenoble</wicri:regionArea>
<placeName><settlement type="city">Grenoble</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chabrol, Claude" sort="Chabrol, Claude" uniqKey="Chabrol C" first="Claude" last="Chabrol">Claude Chabrol</name>
<affiliation wicri:level="3"><nlm:affiliation>University Grenoble Alpes, CEA, LETI, CLINATEC, MINATEC Campus, 38000, Grenoble, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>University Grenoble Alpes, CEA, LETI, CLINATEC, MINATEC Campus, 38000, Grenoble</wicri:regionArea>
<placeName><settlement type="city">Grenoble</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Johnstone, Daniel M" sort="Johnstone, Daniel M" uniqKey="Johnstone D" first="Daniel M" last="Johnstone">Daniel M. Johnstone</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Physiology F13, University of Sydney, Sydney, 2006, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Physiology F13, University of Sydney, Sydney, 2006</wicri:regionArea>
<orgName type="university">Université de Sydney</orgName>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Stone, Jonathan" sort="Stone, Jonathan" uniqKey="Stone J" first="Jonathan" last="Stone">Jonathan Stone</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Physiology F13, University of Sydney, Sydney, 2006, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Physiology F13, University of Sydney, Sydney, 2006</wicri:regionArea>
<orgName type="university">Université de Sydney</orgName>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Benabid, Alim Louis" sort="Benabid, Alim Louis" uniqKey="Benabid A" first="Alim-Louis" last="Benabid">Alim-Louis Benabid</name>
<affiliation wicri:level="3"><nlm:affiliation>University Grenoble Alpes, CEA, LETI, CLINATEC, MINATEC Campus, 38000, Grenoble, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>University Grenoble Alpes, CEA, LETI, CLINATEC, MINATEC Campus, 38000, Grenoble</wicri:regionArea>
<placeName><settlement type="city">Grenoble</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mitrofanis, John" sort="Mitrofanis, John" uniqKey="Mitrofanis J" first="John" last="Mitrofanis">John Mitrofanis</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Anatomy F13, University of Sydney, Sydney, 2006, Australia. john.mitrofanis@sydney.edu.au.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Anatomy F13, University of Sydney, Sydney, 2006</wicri:regionArea>
<orgName type="university">Université de Sydney</orgName>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2016">2016</date>
<idno type="RBID">pubmed:27377070</idno>
<idno type="pmid">27377070</idno>
<idno type="doi">10.1007/s00221-016-4720-7</idno>
<idno type="wicri:Area/PubMed/Corpus">001600</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001600</idno>
<idno type="wicri:Area/PubMed/Curation">001578</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001578</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001578</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001578</idno>
<idno type="wicri:Area/Ncbi/Merge">003799</idno>
<idno type="wicri:Area/Ncbi/Curation">003799</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">003799</idno>
<idno type="wicri:Area/Main/Merge">001A56</idno>
<idno type="wicri:Area/Main/Curation">001A60</idno>
<idno type="wicri:Area/Main/Exploration">001A60</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Near-infrared light treatment reduces astrogliosis in MPTP-treated monkeys.</title>
<author><name sortKey="El Massri, Nabil" sort="El Massri, Nabil" uniqKey="El Massri N" first="Nabil" last="El Massri">Nabil El Massri</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Anatomy F13, University of Sydney, Sydney, 2006, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Anatomy F13, University of Sydney, Sydney, 2006</wicri:regionArea>
<orgName type="university">Université de Sydney</orgName>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Moro, Cecile" sort="Moro, Cecile" uniqKey="Moro C" first="Cécile" last="Moro">Cécile Moro</name>
<affiliation wicri:level="3"><nlm:affiliation>University Grenoble Alpes, CEA, LETI, CLINATEC, MINATEC Campus, 38000, Grenoble, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>University Grenoble Alpes, CEA, LETI, CLINATEC, MINATEC Campus, 38000, Grenoble</wicri:regionArea>
<placeName><settlement type="city">Grenoble</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Torres, Napoleon" sort="Torres, Napoleon" uniqKey="Torres N" first="Napoleon" last="Torres">Napoleon Torres</name>
<affiliation wicri:level="3"><nlm:affiliation>University Grenoble Alpes, CEA, LETI, CLINATEC, MINATEC Campus, 38000, Grenoble, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>University Grenoble Alpes, CEA, LETI, CLINATEC, MINATEC Campus, 38000, Grenoble</wicri:regionArea>
<placeName><settlement type="city">Grenoble</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Darlot, Fannie" sort="Darlot, Fannie" uniqKey="Darlot F" first="Fannie" last="Darlot">Fannie Darlot</name>
<affiliation wicri:level="3"><nlm:affiliation>University Grenoble Alpes, CEA, LETI, CLINATEC, MINATEC Campus, 38000, Grenoble, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>University Grenoble Alpes, CEA, LETI, CLINATEC, MINATEC Campus, 38000, Grenoble</wicri:regionArea>
<placeName><settlement type="city">Grenoble</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Agay, Diane" sort="Agay, Diane" uniqKey="Agay D" first="Diane" last="Agay">Diane Agay</name>
<affiliation wicri:level="3"><nlm:affiliation>University Grenoble Alpes, CEA, LETI, CLINATEC, MINATEC Campus, 38000, Grenoble, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>University Grenoble Alpes, CEA, LETI, CLINATEC, MINATEC Campus, 38000, Grenoble</wicri:regionArea>
<placeName><settlement type="city">Grenoble</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chabrol, Claude" sort="Chabrol, Claude" uniqKey="Chabrol C" first="Claude" last="Chabrol">Claude Chabrol</name>
<affiliation wicri:level="3"><nlm:affiliation>University Grenoble Alpes, CEA, LETI, CLINATEC, MINATEC Campus, 38000, Grenoble, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>University Grenoble Alpes, CEA, LETI, CLINATEC, MINATEC Campus, 38000, Grenoble</wicri:regionArea>
<placeName><settlement type="city">Grenoble</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Johnstone, Daniel M" sort="Johnstone, Daniel M" uniqKey="Johnstone D" first="Daniel M" last="Johnstone">Daniel M. Johnstone</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Physiology F13, University of Sydney, Sydney, 2006, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Physiology F13, University of Sydney, Sydney, 2006</wicri:regionArea>
<orgName type="university">Université de Sydney</orgName>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Stone, Jonathan" sort="Stone, Jonathan" uniqKey="Stone J" first="Jonathan" last="Stone">Jonathan Stone</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Physiology F13, University of Sydney, Sydney, 2006, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Physiology F13, University of Sydney, Sydney, 2006</wicri:regionArea>
<orgName type="university">Université de Sydney</orgName>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Benabid, Alim Louis" sort="Benabid, Alim Louis" uniqKey="Benabid A" first="Alim-Louis" last="Benabid">Alim-Louis Benabid</name>
<affiliation wicri:level="3"><nlm:affiliation>University Grenoble Alpes, CEA, LETI, CLINATEC, MINATEC Campus, 38000, Grenoble, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>University Grenoble Alpes, CEA, LETI, CLINATEC, MINATEC Campus, 38000, Grenoble</wicri:regionArea>
<placeName><settlement type="city">Grenoble</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mitrofanis, John" sort="Mitrofanis, John" uniqKey="Mitrofanis J" first="John" last="Mitrofanis">John Mitrofanis</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Anatomy F13, University of Sydney, Sydney, 2006, Australia. john.mitrofanis@sydney.edu.au.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Anatomy F13, University of Sydney, Sydney, 2006</wicri:regionArea>
<orgName type="university">Université de Sydney</orgName>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Experimental brain research</title>
<idno type="eISSN">1432-1106</idno>
<imprint><date when="2016" type="published">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (pharmacology)</term>
<term>Analysis of Variance</term>
<term>Animals</term>
<term>Corpus Striatum (metabolism)</term>
<term>Corpus Striatum (pathology)</term>
<term>DNA-Binding Proteins (metabolism)</term>
<term>Disease Models, Animal</term>
<term>Female</term>
<term>Glial Fibrillary Acidic Protein (metabolism)</term>
<term>Gliosis (etiology)</term>
<term>Gliosis (therapy)</term>
<term>Infrared Rays (therapeutic use)</term>
<term>MPTP Poisoning (complications)</term>
<term>MPTP Poisoning (pathology)</term>
<term>Macaca fascicularis</term>
<term>Male</term>
<term>Neuroglia (drug effects)</term>
<term>Neuroglia (radiation effects)</term>
<term>Neurotoxins (toxicity)</term>
<term>Substantia Nigra (drug effects)</term>
<term>Substantia Nigra (metabolism)</term>
<term>Substantia Nigra (pathology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>1-Méthyl-4-phényl-1,2,3,6-tétrahydropyridine (pharmacologie)</term>
<term>Analyse de variance</term>
<term>Animaux</term>
<term>Corps strié (anatomopathologie)</term>
<term>Corps strié (métabolisme)</term>
<term>Femelle</term>
<term>Gliose ()</term>
<term>Gliose (étiologie)</term>
<term>Intoxication au MPTP ()</term>
<term>Intoxication au MPTP (anatomopathologie)</term>
<term>Macaca fascicularis</term>
<term>Modèles animaux de maladie humaine</term>
<term>Mâle</term>
<term>Neurotoxines (toxicité)</term>
<term>Névroglie ()</term>
<term>Névroglie (effets des radiations)</term>
<term>Protéine gliofibrillaire acide (métabolisme)</term>
<term>Protéines de liaison à l'ADN (métabolisme)</term>
<term>Rayons infrarouges (usage thérapeutique)</term>
<term>Substantia nigra ()</term>
<term>Substantia nigra (anatomopathologie)</term>
<term>Substantia nigra (métabolisme)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>DNA-Binding Proteins</term>
<term>Glial Fibrillary Acidic Protein</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Corps strié</term>
<term>Intoxication au MPTP</term>
<term>Substantia nigra</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>MPTP Poisoning</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Neuroglia</term>
<term>Substantia Nigra</term>
</keywords>
<keywords scheme="MESH" qualifier="effets des radiations" xml:lang="fr"><term>Névroglie</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Gliosis</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Corpus Striatum</term>
<term>Substantia Nigra</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Corps strié</term>
<term>Protéine gliofibrillaire acide</term>
<term>Protéines de liaison à l'ADN</term>
<term>Substantia nigra</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Corpus Striatum</term>
<term>MPTP Poisoning</term>
<term>Substantia Nigra</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>1-Méthyl-4-phényl-1,2,3,6-tétrahydropyridine</term>
</keywords>
<keywords scheme="MESH" qualifier="radiation effects" xml:lang="en"><term>Neuroglia</term>
</keywords>
<keywords scheme="MESH" qualifier="therapeutic use" xml:lang="en"><term>Infrared Rays</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Gliosis</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Neurotoxins</term>
</keywords>
<keywords scheme="MESH" qualifier="toxicité" xml:lang="fr"><term>Neurotoxines</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Rayons infrarouges</term>
</keywords>
<keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Gliose</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Analysis of Variance</term>
<term>Animals</term>
<term>Disease Models, Animal</term>
<term>Female</term>
<term>Macaca fascicularis</term>
<term>Male</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Analyse de variance</term>
<term>Animaux</term>
<term>Femelle</term>
<term>Gliose</term>
<term>Intoxication au MPTP</term>
<term>Macaca fascicularis</term>
<term>Modèles animaux de maladie humaine</term>
<term>Mâle</term>
<term>Névroglie</term>
<term>Substantia nigra</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">We have reported previously that intracranial application of near-infrared light (NIr) reduces clinical signs and offers neuroprotection in a subacute MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) monkey model of Parkinson's disease. In this study, we explored whether NIr reduces the gliosis in this animal model. Sections of midbrain (containing the substantia nigra pars compacta; SNc) and striatum were processed for glial fibrillary acidic protein (to label astrocytes; GFAP) and ionised calcium-binding adaptor molecule 1 (to label microglia; IBA1) immunohistochemistry. Cell counts were undertaken using stereology, and cell body sizes were measured using ImageJ. Our results showed that NIr treatment reduced dramatically (~75 %) MPTP-induced astrogliosis in both the SNc and striatum. Among microglia, however, NIr had a more limited impact in both nuclei; although there was a reduction in overall cell size, there were no changes in the number of microglia in the MPTP-treated monkeys after NIr treatment. In summary, we showed that NIr treatment influenced the glial response, particularly that of the astrocytes, in our monkey MPTP model of Parkinson's disease. Our findings raise the possibility of glial cells as a future therapeutic target using NIr.</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>France</li>
</country>
<region><li>Auvergne-Rhône-Alpes</li>
<li>Nouvelle-Galles du Sud</li>
<li>Rhône-Alpes</li>
</region>
<settlement><li>Grenoble</li>
<li>Sydney</li>
</settlement>
<orgName><li>Université de Sydney</li>
</orgName>
</list>
<tree><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="El Massri, Nabil" sort="El Massri, Nabil" uniqKey="El Massri N" first="Nabil" last="El Massri">Nabil El Massri</name>
</region>
<name sortKey="Johnstone, Daniel M" sort="Johnstone, Daniel M" uniqKey="Johnstone D" first="Daniel M" last="Johnstone">Daniel M. Johnstone</name>
<name sortKey="Mitrofanis, John" sort="Mitrofanis, John" uniqKey="Mitrofanis J" first="John" last="Mitrofanis">John Mitrofanis</name>
<name sortKey="Stone, Jonathan" sort="Stone, Jonathan" uniqKey="Stone J" first="Jonathan" last="Stone">Jonathan Stone</name>
</country>
<country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Moro, Cecile" sort="Moro, Cecile" uniqKey="Moro C" first="Cécile" last="Moro">Cécile Moro</name>
</region>
<name sortKey="Agay, Diane" sort="Agay, Diane" uniqKey="Agay D" first="Diane" last="Agay">Diane Agay</name>
<name sortKey="Benabid, Alim Louis" sort="Benabid, Alim Louis" uniqKey="Benabid A" first="Alim-Louis" last="Benabid">Alim-Louis Benabid</name>
<name sortKey="Chabrol, Claude" sort="Chabrol, Claude" uniqKey="Chabrol C" first="Claude" last="Chabrol">Claude Chabrol</name>
<name sortKey="Darlot, Fannie" sort="Darlot, Fannie" uniqKey="Darlot F" first="Fannie" last="Darlot">Fannie Darlot</name>
<name sortKey="Torres, Napoleon" sort="Torres, Napoleon" uniqKey="Torres N" first="Napoleon" last="Torres">Napoleon Torres</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001A60 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001A60 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Asie |area= AustralieFrV1 |flux= Main |étape= Exploration |type= RBID |clé= pubmed:27377070 |texte= Near-infrared light treatment reduces astrogliosis in MPTP-treated monkeys. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:27377070" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a AustralieFrV1
This area was generated with Dilib version V0.6.33. |